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Endocrinology Targeting the central melanocortin system for the treatment of metabolic disorders 2023 DOI: 10.1038/s41574-023-00855-y PMID: 37365323 Sweeney P, Gimenez LE, Hernandez CC, et al

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Ageing and age-associated GH decline research GH pulse amplitude and frequency decline progressively with age a phenomenon termed somatopause associated with reduced GHRH drive and increased somatostatin tone