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doi: 10.3389/fped.2021.647925 Received 30 December 2020 Accepted 12 April 2021 Published 12 May 2021 Volume 9 - 2021 Edited by Kuender D

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[6] More serious claims such as helping with heavy metal toxicity and autism spectrum disorder have been made by various proponents

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In addition, they suggest that cotinine may act through both nAChRs- and non-nAChR-mediated mechanisms, which echoes findings implicating cotinines binding and interactions with both nAChRs and other protein targets reviewed above