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[7] Marketing [edit] Kool cigarette advertising began with the character of "Willie" the penguin, [8] [9] who was portrayed as several different professions, among which were a doctor, a soldier and a chef

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Although nicotine is recognized as a component responsible for adverse vascular effects caused by cigarette smoking, several lines of evidence show that nicotine-free cigarette smoke extract (N()-CSE) substantially impairs endothelial NO-dependent relaxation [4,5,6]