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This binding occurs across all layers of the prefrontal cortex, where nAChRs can directly alter pyramidal neuron activity and disrupt normal signaling patterns

Flavoring chemicals in E-cigarettes: diacetyl, 2,3-Pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-Flavored E-cigarettes

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this was true for all alcohol use categories examined

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