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This explains why the digestive effects of smoke-free nicotine products like ZYN can differ from cigarettes

Biochem J 277(Pt 1):133138 Gairola CG et al (2001) Sidestream cigarette smoke accelerates atherogenesis in apolipoprotein E-/- mice

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The nicotine in the tobacco is absorbed through the lining of the mouth, providing users with a nicotine hit without the need to smoke

INH is a prodrug that enters the Mtb cytoplasm via passive diffusion, where it inhibits mycolic acid synthesis by targeting the InhA enzyme, an essential catalyst in an early step of the mycolic acid biosynthetic pathway (Mitchison, 1956)