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Nicotine directly binds nAChRs along dopamine neuronal cells, facilitating burst firing and increased dopamine activity directly (96), which, combined with enhanced glutamatergic tone, leads to an overall increased level of dopamine transmission and release in the NAc that supports the reinforcing effects of nicotine (97)

It was with a man I regard as one of the most imaginative writers for stage and screen this country has produced, the creator of TV's Twilight Zone (1959-1964) and Night Gallery (1969-1973)

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Int J Toxicol