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Additionally, log-transformed AUC and C mean of PM 10 , PM 2.5 and PM 1 with homogeneous variances (Bartletts test, p = 0.18) were tested for significant differences between the five tobacco products, using one-way ANOVA and Tukey posthoc tests

However, the route, speed and amount of nicotine absorption (and subsequent nicotine levels in plasma) are important determinants of the efficacy of ECs to serve as smoking substitutes and of any concerns about nicotine overdose or intoxication