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Despite the similarly large decreases in body weight, the Sema group showed significant lean mass loss compared to the control group during the 4-week treatment period, while the Sema + -MSTN/-ActA group was not only protected against this lean mass loss, but also had a significant increase in lean mass (Fig

The process is generally irreversible

while in rats it is highly expressed in the C-cells of this organ, there appears to be little detectable expression in non-human primate and human C-cells (85, 88)