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Future research would need to determine the neuropharmacological mechanisms by which smoking increases unpleasant residual effects of very heavy drinking and whether these same mechanisms play a role in harmful interactions, such as the adverse effects on brain structure, metabolites, cerebral blood flow, and neurocognition found among hazardous drinkers or alcoholics who also smoke (Durazzo et al., 2007)

Geneva: World Health Organization (2013)

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Then, they divided the mice into the control group and WIN-treated group