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However, given the number and frequency of cigarettes smoked in Tobacco Nation, it is both dismaying and unsurprising Tobacco Nation residents are more likely to die from cancer, heart disease, and chronic lower respiratory disease than those living in the rest of the U.S

Although specific adverse effects of e-cigarettes on the cardiovascular system could be investigated further,125126 such effects, if they exist, are unlikely to be as harmful as the high risk of cardiovascular disease associated with light smoking that we show here

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We also excluded men with incomplete information on cigarette or cigar use or demographic characteristics (i.e., race/ethnicity, education and marital status), so the final sample for our analyses was 43,202 men (age 4059 years, n = 27,229 and age 5079 years, n = 15,973) with 588,761 person-years and 14,657 deaths