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30 Nicotine is metabolized primarily to cotinine, which is further metabolized to trans-3-hydroxycotinine (3HC), catalyzed by the liver cytochrome P450 2A6 enzyme

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Some of the many tobacco-related events in American history, for example, include the 1964, 1988, and 2020 Surgeon Generals reports, the 2000 truth campaign, the 2009 Family Smoking Prevention law, the 2018 Every Try Counts campaign, and the 2020 federal tobacco control strategic plan 7,8,9,10,11,12