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And if you vape more or you smoke more, then youre going to get more harmful effects. Its a similar story with one of the best-known ingredients in e-cigarettes, cigarettes, pouches and other tobacco products: nicotine

PMC 1419177

McCann J, Gold LS, Horn L, McGill R, Graedel TE, et al

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In particular, it is reported that cEDS patients may show delayed motor development with mild hypotonia, characteristic facial features, fatigue and muscle cramps, premature rupture of fetal membranes, cervical insufficiency during pregnancy, rectal prolapse in early childhood, mild scoliosis, and cardiac/blood vessel fragility including mitral/tricuspid valve prolapse, and aortic root dilatation