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Thus, any potential tax revenue gains from sales can be offset by economic losses related to lowered workforce productivity (e.g., more people take days off work to recover from the effects of use) as well as health care costs

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Functional enrichment for biological processes and signaling pathways was performed via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotations with the clusterProfiler package (version 4.6.2) in R, which utilizes gene sets from MSigDB

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