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This approach has significant potential, given the unique vulnerability of cancer cells to oxidative stressa characteristic that can be exploited for therapeutic benefit
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The mutual outcome of these two effects is the upregulation of hepatic BA formation and emission of conjugated BAs into the blood circulation, which distally anchors the FXR in the bone marrow, resulting in the loss of osteoblast function, negatively impacting BMD, bone volume fraction, and fracture resistance (115)
doi:10.1080/14656566.2017.1308483CrossRefGoogle ScholarPubMed Chez, MG, Burton, Q, Dowling, T, Chang, M, Khanna, P, Kramer, C