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However, given that the true oncogenic risks of long-term E-cigarette use in human populations may not be apparent for decades given the relatively recent advent of these cigarette alternatives such that these analyses cannot be readily performed at present, we believe that our findings highlight the potential risks of E-cigarette use, providing a strong foundation for future studies focused on the role that EVs play as facilitators of field cancerization and tumor recurrence in this context and more broadly

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