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Nonparametric data were analysed with the MannWhitney U test (for two groups) or the KruskalWallis test (multiple groups) followed by Dunn's post hoc

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The core message is blunt and aimed squarely at current smokers and their clinicians: The primary public health message of our paper is the importance of complete smoking cessation at younger ages. Cutting back from a pack a day to a few cigarettes a day does reduce risk, but this new analysis shows that even those few cigarettes still carry substantial danger, and that simply reducing intensity is a poor substitute for stopping altogether