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Third, while our data support involvement of the MKK3/p38 MAPKPRKN Ser131 pathway in mitophagy impairment and senescence, additional studies using primary human airway epithelial cells and further in vivo validation will be important to strengthen the evidence base and translational relevance

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The recommendations declare a vision and direction for those policy and system changes which the Tobacco Control Network membership believe are most important to reducing and eliminating the health issues caused by tobacco use and secondhand smoke exposure

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