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Once open and, if kept refrigerated, the shelf life is 6 months

As a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist, Semaglutide has become one of the most extensively studied peptides in metabolic research, with ongoing investigations focused on glucose regulation, appetite signaling, energy metabolism, endocrine function, and gastrointestinal physiology

For broader medication safety in the compounded space, see (Hoffman et al., 2025) on FDA Adverse Event Reporting System data for compounded GLP-1 quality issues, is compound tirzepatide safe, and does compounded tirzepatide work

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