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The effect was dose-dependent: the more someone used per week, the worse their vascular function. Worryingly, even relatively small doses of 2.5mg multiple times a week seemed to have a harmful effect

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To him, more than any other man in America, was due the great vogue of vomits, purging, and especially of bleeding, salivation and blistering, which blackened the record of medicine and afflicted the sick almost to the time of the Civil War Benjamin Rush has been hailed as the American Sydenham, the Pennsylvania Hippocrates, the father of modern psychiatry, and the founder of American medicine. The American Medical Association erected a statue of him in Washington, DC, the only physician so honored

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