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More important than the treatment effects, perhaps, are the overall low rates of treatment engagement (19.8%) and low rates of incentive treatment acceptance, defined as agreeing to the incentive contract (51.2%)

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Because elderly patients frequently have inefficient function of one or more organ systems and because dosage requirements have been shown to decrease with age, reduced initial dosage of midazolam is recommended, and the possibility of profound and/or prolonged effect should be considered