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For our Individual-Level Life Expectancy analyses, we found the following: ( i ) setting the mortality probabilities for NS to their upper and lower confidence bounds changes life expectancy estimates by approximately 1 year or less ( 1.4%) in all subpopulations except for SPD, in whom life expectancy estimates change by up to 2.6y (3.3%) for women and 3.5y (4.8%) for men (Additional File 1, Supplementary Table 1)

Main text Epigenetic alterations include three major modifications: DNA modifications via methylation

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