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PMID 35145979

This risk may be higher for individuals who smoke cigars frequently or for long periods

Cigarettes are made from: Tobacco , selected according to specific blends and leaf grades to maintain the consistency and distinctive character of each brand Ingredients , added to many of PMIs brands to keep the tobacco moist, aid the manufacturing process, replenish natural sugars lost during leaf curing, and contribute to each brands unique taste Nontobacco materials , such as paper or filters The selection of the right tobacco blend is the first step in cigarette production

Bob Sheetz started it in 1952

Several non-nicotine constituents found in CS extract could account for its greater aversive/anhedonic effects compared to nicotine alone