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Similarly, children who experienced parental absence were 46 per cent more likely to have started drinking alcohol by the age of 11 Having an absent parent has previously been linked to an increased likelihood of children smoking and drinking in adolescence

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Moreover, shared developmental [8,9,10,11] and genetic [2, 12, 13] vulnerabilities interact with environmental factors [14, 15], collectively increasing risk across drug classes and sustaining persistent polysubstance use and use disorders