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Oliveira et al., 2020

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A disease of brain reward centers (Dackis and OBrien, 2005) DEFINITION OF A DRUG Articles other than food intended to affect the structure or any function of the body of man (F.D.A., 1938) CRITERIA FOR ADDICTION:WORLD HEALTH ORGANIZATION A behavioral pattern in which the use of a given psychoactive drug is given a sharply higher priority over other behaviors which once had a significantly higher value. 57 yo smoker with coronary heart disease, recent bypass surgery, and severe hypertension, on multiple antihypertensive medications