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Sublingual glutathione bypasses first-pass metabolism but still requires enzymatic breakdown by oral mucosal GGT, and plasma levels remain low

Dehydration interferes with the body's ability to break down fat and turn it into fuel

This may include delaying decisions about food, substituting high calorie snacks with lighter options, improving hydration, or using distraction techniques such as walking, stretching, or starting a brief task

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[7] So the honest one-line summary is that both build on GLP-1 but recruit a different second pathway amylin for CagriSema, GIP for tirzepatide and there is a further structural difference underneath that: CagriSema achieves its dual action with two separate peptides, while tirzepatide achieves its dual action with one