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Chronic, low-grade inflammation due to gingivitis downregulates nitric oxide, eventually leading to coronary endothelial dysfunction.[ref][ref] The bacteria that cause periodontal disease, P

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Fernandes DM, Oliveira CR, Guerguis S, Eisenberg R, Choi J, Kim M, Abdelhemid A, Agha R, Agarwal S, Aschner JL, Avner JR, Ballance C, Bock J, Bhavsar SM, Campbell M, Clouser KN, Gesner M, Goldman DL, Hammerschlag MR, Hymes S, Howard A, Jung HJ, Kohlhoff S, Kojaoghlanian T, Lewis R, Nachman S, Naganathan S, Paintsil E, Pall H, Sy S, Wadowski S, Zirinsky E, Cabana MD, Herold BC

Wood, Thiamin, in Present Knowledge in Nutrition, fifth edition (Washington D.C.: Nutrition Foundation, 1984), pp