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No concrete evidence of exactly what they smoked exists, but the most probable theory is that the tobacco was much stronger, consumed in extreme amounts, or was mixed with other, unknown psychoactive drugs

The LOD and LOQ of ETS-V were three times and ten times the standard deviation of the smallest concentration of standards, respectively

The insula ties in with those systems and could be a key part of the pathway that sets people up for relapse should they try to quit

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