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However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials

SST acts via a seven trans-membrane, G protein coupled receptor and, thus far, five subtypes of the receptor have been identified in humans (SSTR1-5)

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The intranasal route is particularly effective because it delivers the peptide directly to the brain through the olfactory mucosa, bypassing first-pass metabolism and the blood-brain barrier entirely

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