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A 2022 analysis by the Pharmacy Benefit Management Institute estimated that spread pricing extracted $1 billion to $3 billion annually from commercial plan sponsors in the U.S

[DOI] [PMC free article] [PubMed] [Google Scholar] Romano N., Koh C.-B., Ng W.-K

Researchers became interested because early studies showed that combining these peptides produced accelerated healing timelines and improved tissue quality outcomes compared to individual peptide applications