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Increasing SLC25A51 expression has been demonstrated to enhance mitochondrial NAD + uptake, thereby maintaining SIRT3 activity and regulating lipid homeostasis through AMPK

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Immunofluorescence staining also showed a marked increase in the number of Ki-67-positive cells and a decrease in the nuclear content of -H2AX and P21 after FOXO4-DRI treatment (Figures 4B,C)