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Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults

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By maintaining the integrity of the mitochondrial membrane and inhibiting the release of apoptogenic chemicals, Bcl-2 suppresses apoptosis (Zupo et al

In addition, TGF-1 expression was significantly increased in the airway epithelium of both smokers and COPD patients, accompanied by the expression of Smad2/3 [16, 106]