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We hypothesize that smoke-mediated activation of the parthanatos pathway of programmed cell death produces inflammation that if chronic, results in airway remodeling

Notably, an analogous discrepancy exists between the results of RCTs and cohort studies regarding the effectiveness of nicotine replacement products, but because these products were consistently shown to be efficacious in numerous RCTs the efficacy of these products is well established (Fiore et al., 2008

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