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Delayed healing : The chemicals in cigarette smoke can slow down the healing process and increase the risk of infection
Second, neurogenic inflammation resulting from tobacco smoke exposure may serve as a pathway distinct from antigen-driven, immune-mediated inflammation to produce vasodilatation, edema and infiltration of leukocytes 27
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[114] The first report documents an English sailor in Bristol in 1556, seen "emitting smoke from his nostrils"
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