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Cigarette smoke's chemicals affect cardiovascular systems, reducing blood flow

Glutamate, stimulated by NMDARs, regulates dopamine neurons that project from the ventral tegmentum area (VTA) toward the nucleus accumbens (NAc) or the prefrontal cortex (PFC), as well as GABA neurons that also play a role in regulating dopamine neurons (88)

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The combination of CBD, minor cannabinoids, and terpenes all contributes to the overall feel and character of each CBD cigarette