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Considering the subtle membrane changes that are usually induced by smokeless tobacco due to its ability to generate free radicals which have been implicated with hepatic injuries and which when persistent may cause liver cirrhosis, at 4 weeks stage of the study, groups B, C and D showed cellular necrosis, inflammatory cell infiltration, hemorrhagic exudations, degenerative fatty changes with vacuolations, severe cellular infiltration with hemorrhage and distortions in parenchymal tissue architecture with hemorrhagic exudations Fig

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Reduced oxygen delivery Using tobacco products introduces nicotine and carbon monoxide into the blood, which reduces the amount of oxygen in the blood