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In the rarer types of EDS, there is also weakness of specific tissues that can lead, for example, to major gum and dental disease, eye disease, cardiac valve and aortic root disorders, and life-threatening abdominal organ, uterine, or blood vessel rupture

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Its headquarters are located in Raleigh, North Carolina, though its major manufacturing facilities are in Mebane, North Carolina and in Danville, Virginia

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