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Although nicotine absorption from ONP through buccal cell membranes is rapid, the rise in the brain nicotine level appears to be slower than with inhalable products

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however, further research is needed to examine the clinical value of TBS for treating substance use disorders. Reference: Effects of Hyperdirect Pathway Theta-Burst Transcranial Magnetic Stimulation on Inhibitory Control, Craving, and Smoking in Adults with Nicotine Dependence: A Double-Blind Randomized Crossover Trial by Spencer Upton, Alexander A

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They were classified based on the question, Do you currently use smokeless tobacco daily, less than daily, or not at all?