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Among former smokers, increased smoking amount per day ( p = 0.008), duration in years ( p = 0.007), and cumulative amount in pack-years ( p = 0.003) was associated with increased tumor aggressiveness

Future research should address this limitation by incorporating out-of-pocket costs to provide a more comprehensive understanding of the economic impact of tobacco-related morbidity

Instead, the cells with damaged DNA go on to divide uncontrollably, leading to the development of tumors (bottom row)

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