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Equipment and Utility Change Control for GMP Production Facilities By Greg Weilersbacher Despite FDAs guidance documents on change control, managing change to prevent unintended consequences, many companies limit change control to documentation such as batch records, SOPs, protocols, and specifications and only sporadically

The difference matters because the inputs that shape tobacco demand don't sit still: Competitor pricing moves State-level regulatory changes Shifts in consumer mix by income and age Cross-border purchasing dynamics For tobacco companies, forecast accuracy extends well beyond pricing

Cigarettes with defective filters marketed for 40 years: what Philip Morris never told smokers

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2 4 , 25 Aggressive marketing campaigns have also led to the renormalization of smoking, 25 with the U.S