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Additionally, the applicant did not present sufficient data demonstrating that the new products have a potential to benefit adult smokers, in terms of complete switching or significant cigarette use reduction, that would outweigh the risk to youth, according to the agency.

The authors also would like to thank Antonio Ramazzotti for reviewing and providing insightful comments on this publication

However, one major different between Halo and Vuse, is availability

Mainstream and sidestream smoke negatively impacts sperm chromatin quality and decreases fertilization rates, while male secondhand smoke exposure before use appears to be deleterious for reproductive success

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