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It should get smaller and lighter in color

The therapeutic effects of berberine in cardiovascular disease, gastrointestinal disease and endocrine disease. Frontiers in Pharmacology, 2021

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Severe, persistent pain in the upper abdomen or middle back that is constant and worsening is the primary warning sign of pancreatitis

Overall our data contradict these previous findings, with the reasons underpinning likely being related to the timing of GLP-1 initiation, dosing of liraglutide, duration of treatment and the agent choice