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"Once you have a substance out there like tobacco in wide use it's hard to turn around and make it illegal," said Arthur Caplan, a bioethicist at New York University School of Medicine's Division of Medical Ethics, "You can certainly tax it, you can certainly stigmatize it," and educate against its use

E-cigarette signage posted in these areas must be heeded

Many have speculated that the company was sensitive to Honus Wagner's own objection to the production of the card because, it is commonly believed, he was reluctant to allow his image to be associated with any tobacco-related products

These products are not zero-risk, Calantzopoulos said