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Current standards recommend assessing retinopathy status when glucose-lowering therapy is intensified and ensuring an eye exam within the last 12 months for many patients with diabetes

22 However, the fact that the magnitude and speed of hemoglobin A1c reduction with treatment were identified as risk factors for progression suggests it could be another example of the well-established early worsening phenomenon first observed in type 1 diabetic patients intensively treated with insulin in the Oslo Study, Kroc Collaborative Study and Diabetes Control and Complications Trial

By 2045, the number of DM patients could soar to a staggering 783.2 million [3, 4]

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doi: 10.1016/j.ncl.2021.01.005 [PubMed] Erstad BL , 2022