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Toxic effects of nicotine include: Triggering acute increases in heart rate and blood pressure Impairing the ability of blood vessels to expand and contract as needed Promoting blood clots, which increases risk of heart attack and stroke Causing scarring to the heart Promoting growth of new blood vessels, which can feed cancers The highly addictive nature of nicotine ensures that all of these toxic effects will be endured repeatedly and over the long term, researchers concluded

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Officials at the FDA say applications for new products have languished because of "significant deficiencies" and because the agency is taking extra care in reviewing products that pose public health risks

As newer iterations brought higher levels of nicotine in an increasing array of flavors and product designs, youth use skyrocketed

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