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The decline has also indirectly impacted the sales of other products

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Assessment of genetic damage among chewers of mixture containing mainly areca nut and tobacco

There is good evidence, but not with absolute certainty, that the smoke with the more cancer-causing agents gets deeper to the lungs where adenocarcinomas more commonly occur. Efforts to contact major tobacco companies and industry groups for comment on this study were not successful

Higher doses, such as 4 mg gum or 21 mg patches, are generally more effective than lower doses