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Triggers: Outdoor: pollen, mold, smoke ( seasonal allergies dogs ) Indoor: dust, cleaning products ( indoor allergens dogs ) Symptoms: Respiratory signs: sneezing, reverse sneezing, coughing, wheezing, nasal discharge Eye and nose irritation: itchy eyes, watery discharge, fatigue Behavioral changes: restlessness, reduced playfulness, excessive grooming Research Insight: A 2020 study in Veterinary Record showed that dogs exposed to multiple environmental allergens were more likely to develop chronic sneezing and labored breathing (Bizikova et al., 2020)

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(2) reporting a serious, unstable psychiatric condition (e.g., bipolar disorder, schizophrenia), (3) reporting a serious, unstable physical health condition that would increase risk of study participation determined by medical history interview and review by study physician (e.g., past or present cardiac problems, respiratory problems, overnight hospitalization in the past 3 months), (4) current criteria for DSM-5 moderate or severe cannabis use disorder, (5) current use of other psychoactive substances confirmed by urine drug screening, unless prescribed and stable for 2 months, (6) living with someone who currently smokes menthol cigarettes, to reduce access to preferred cigarettes during the switching phase of the study, consistent with our pilot [19], (7) known allergy to PG/VG in e-liquid, (8) female participants will be excluded if they are currently pregnant, planning to become pregnant, breastfeeding, or unwilling to use an effective method of birth control for the duration of the study, (9) abnormal spirometry test, (10) if reporting recent cannabis vaping (past 90 days), additional exclusion will be any report of mild or greater EVALI-related symptoms (e.g., cough, shortness of breath, chest pain) without non-EVALI reasonable and proximal cause