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Chronic nicotine (6 mg/kg/day) exposure using minipumps for 12 days also decreases the mRNA expression of serotonin transporters in the dorsal raphe in male Wistar rats, suggesting alterations in the concentrations of serotonin within the mesocorticolimbic system (Semba and Wakuta, 2008)

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Dealing with cigarette waste is one of the worlds most difficult environmental dilemmas: billions of cigarettes are littered worldwide each year, causing millions of tonnes of toxic waste containing metals like arsenic, chromium, nickel, and cadmium to be released into soil and waterways