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Benoist 2011, PMID 21719467, which studied Nle1-AngIV analogs rather than Dihexa itself)

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Regulation of other signaling pathways In addition to Nrf2 and insulin signaling pathways, lipoic acid was found to target other cell-signaling molecules thereby affecting a variety of cellular processes, including metabolism, stress responses, proliferation, and survival

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Verdict: Limited evidence the tendon and ligament claims have a plausible biological basis, but they remain unconfirmed in human recovery studies [35][7]