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Residual-Solvent Testing Appropriate gas-chromatography or other validated methods should assess solvents used during synthesis and purification

Battelino T, Bergenstal RM, Rodrguez A, Fernndez Land L, Bray R, Tong Z, et al

78 In the microenvironment, cancer cells consume glutamine to synthesize -aminobutyric acid (GABA) via glutamate decarboxylase 1 (GAD1)

However, this GABA-induced inhibition of glutamate release is disturbed in patients with CAs [77]

Persistent or worsening nausea beyond this timeframe should prompt reassessment for drug interactions, alternative diagnoses (e.g., gastroparesis), or consideration of anti-nausea medications