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Indeed, nicotine triggers oxidative stress in the testis, resulting in a global alteration of testis function, with a decrease in testosterone level, lower epididymal sperm number and viability, and increased levels of apoptosis in spermatogonia and spermatocytes [53,54,55,56]

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Thus, the estimated net smuggling numbers for Delaware and the states that surround it do not "cancel out" as might be expected absent consideration of other state smuggling flows

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